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[xii], 262, [8] pp. Additional illustrated title page. 18 numbered anatomical engravings (8 full page, one of which (12) is an inserted plate; 2 other small engravings, woodcut  head- and tail-pieces, initial letters. (Folio) 28.2x17.9 cm (11¼x7") period full calf. Custom cloth case. First Edition.

A reflection of the slow acceptance of revolutionary ideas, Highmore's work was the first textbook on anatomy to accept Harvey's theory of the circulation of the blood, which Harvey had first published twenty-three years earlier, in 1628. The striking engraved title of the volume incorporates the theory of the circulation into an engraved representation of the human body as a garden. Also contains the first description of the "antrum of Highmore" (maxillary sinus) and of the corpus Highmori (mediastinal testis). Provenance: Franz Keibel (1861-1929), important embryologist (bookplate); Harvard Medical Library, Gift of Frederic T. Lewis (bookplate); The Dean Edel Collection (sold Christies 10/2007); George Bray.